medskin 800mg



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Acyclovir .............................. 800 mg

Excipients q.s........................ 1 tablet

(Microcrystalline cellulose M101, wheat starch, ponceau, PVP K30, colloidal silicon dioxide, magnesium stearate, talc).


PRESENTATION: Box of 3 blisters x 10 tablets.


Acyclovir is similar to tướng nucleoside. It interferes DNA synthesis and inhibits selectively viral replication, resulting in not affecting the metabolism of normal cells. Acyclovir is potently active against Herpes simplex virus type 1 (HSV-1) and less active against Herpes simplex virus type 2 (HSV-2) and Varicella zoster virus (VZV), cytomegalovirus (CMV).


Oral bioavailability of acyclovir is about 20%. Oral acyclovir is mainly absorbed by the GI tract; the influence of food on the absorption of acyclovir was not apparent. Acyclovir is widely distributed in toàn thân fluids and organs including brain, kidney, lung, intestine, liver, spleen, uterus, mucosa, vaginal mucosa, tears, aqueous humor, seminal fluid, encephalospinal fluid. Plasma protein binding is relatively low (9 to tướng 33%). Peak plasma concentrations of acyclovir usually occur with 1.5 to tướng 2 hours. The elimination half-life of acyclovir is approximately 2 to tướng 3 hours. Acyclovir is excreted principally in the kidneys as unchanged; a small amount of acyclovir is metabolized by the liver.


reatment of initial and recurrent infections due to tướng Herpes simplex virus type 1 and type 2 on skin and mucosa, Herpes simplex encephalitis.

Treatment of acute Herpes zoster infections (shingles), ocular shingles, pneumonia due to tướng Herpes zoster in adults.

Treatment of initial and recurrent infections of genital Herpes.

Treatment of haemorrhagic chickenpox, chickenpox in immunodeficiency patients, chickenpox in newborn baby.


Hypersensitivity to tướng any components of the drug.


Renal failure has been observed with acyclovir therapy.

Caution should also be exercised when administering acyclovir to tướng patients receiving potentially nephrotoxic agents.

Do not exceed the prescribed doses and the treatment period of time.


Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to tướng the fetus.

Acyclovir concentrations have been documented in breast milk. It should be administered to tướng a nursing mother with caution.


The drug does not affect the ability to tướng drive and use machinery.


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Concurrent use of zidovudine and acyclovir may cause states of doze and deep sleep.

Probenecid is reported to tướng inhibit the renal elimination of acyclovir, reduce the uric excretion and the purification of acyclovir.

Amphotericin B and ketoconazole enhance the antiviral effect of acyclovir.


Side effects in patients treated short-term with acyclovir are nausea, vomiting. Long-term treatment over 1 year has the potential for nausea, vomiting, diarrhea, colic, rash, headache (<5% of patients).

Inform your physician about any adverse effects occur during the treatment.


Symptoms: Precipitation of acyclovir in renal tubules may occur when renal concentrations is excreted the solubility (2.5 mg/ml) or the serum creatinine is elevated. Adverse events that have been also reported in association with overdosage include renal failure, excitement, anxiety, convulsion, palpitation, hypertension, and dysuria.

Management: Hemodialysis is advised until recovery of renal function. The drug should be discontinued and patients should receive fluids and electrolytes.


For treatment of Herpes simplex infections:

- Adults and children aged > 2 years: oral dose of 200 mg (400 mg in immunodeficiency patients) 5 times daily every 4 hours for 5 - 10 days.

For suppression of recurrent Herpes simplex in immunocompromised patients, visceral transplant patients using the hypo-immune drugs, HIV-infected person, chemotherapy-treating individuals.

- Adults and children aged > 2 years: oral dose of 200 - 400 mg, 4 times daily.

For treatment of chickenpox and shingles:

- Adults: oral dose of 800 mg 5 times daily, for 7 days.

- Children: oral dose of đôi mươi mg/ kilogam body-weight (maximum of 800 mg), 4 times daily for 5 days.

For patients with renal impairment: The dose for patients with renal impairment associated with HSV or Varicella zoster infections is similar to tướng that of normal patients. However, the dose should be modified as follows:

- Creatinine clearance of 10 - 25 ml/ min: taking every 8 hours.

- Creatinine clearance of below 10 ml/ min: taking every 12 hours.

Or as directed by the physician.

Read the directions carefully before use.           

Consult the physician for more information.                

This drug is for prescription only.           

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Shelf-life: 36 months from the manufacturing date.

Storage conditions: Store in dry places, not exceeding 30oC, protect from light.

Specifications: Manufacturer's.